This is the most serious and musically astute, and historic, advice anyone can give you about playing a six string guitar.
Please, look up Orville Gibson, who in 1850 began Gibson guitars.
He played a guitar he built for himself, being left-handed, and his bass strings were at the bottom of the fretboard.
Like a violinist or cellist, or a contra-euphonic valve instrument, and a piano, the bass is left and the highs are right.
I believe a left-handed person invented the guitar as we know it, and righties turned it upside down.
Mr. George Benson laughed a lot, sitting with me in his dressing room, taking turns with his guitar, but he agreed it could be true.
He described playing the high E as "scrunching up your fingers", making any note use difficult,
compared to reaching across the fret-board where your fingers can move freely in any direction,
and if you are bending the strings you are reaching across to pull them down, a natural movement,
not trying to get the end of your finger on them to push them, when reaching across allows fingertips to bottoms.
When Jeff Healey's drummer called me over to meet Jeff, sitting in his local bar,
Jeff thought I was sitting with my guitar on my lap like him, pulling big bends as he did.
Jimi Hendrix also played bass on the bottom and right-handed, trying to do it all.
The best thing about playing with bass on the bottom is that your barre chord finger is reaching up to the highs,
so the bottom pad of your finger, the strongest part, is holding the bass down, or is positioned over it, all the time.
Your fingertips are better positioned to play the high strings, where you want your best dexterity.
Imagine playing chords where, if you want, you can just move your hand so the bass notes are pressed down,
and if you're using feedback where you have to dampen any string you aren't fingering,
that just happens naturally with a hand movement, not the use of individual fingers.
Even if you're not musical with barre chords yet,
all you have to do is try holding the strings down both ways to see bass on the bottom feels more effortless.
There's a reason why electric lead guitarists haven't reached the acclaim of being considered as virtuosos,
and I know, as one of the first symphonic-electric guitarists, that having to scrunch up your fingers is why.
If that's not true, I'm going to have to order a custom made left-handed piano,
or turn my photo of Nicolo Paganini around to make him look like he's playing the other way.
After-edit additions!
You know how some classical guitarists can never use their little to middle fingers, the three of them,
to pick a high string quickly, making fast notes, despite practicing this co-ordination all their lives?
That's easy to do the first time you try, using your thumb to middle finger, highs on top.
http://www.youtube.com/watch?v=oNgSeJzLJFc
Here's the Gypsy Kings! See the lefties and see who is playing bass on the bottom.
I know, I know, bass on the bottom, highs on top, what a concept!
And yes, you can still play guitar real easy and still have the blues.
http://www.youtube.com/watch?v=gopiZc1F_Yk